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尽管对结核病的治疗和免疫预防已取得了很大的进展,但结核病仍然是主要的传染疾病,虽然能治愈,但至少需6~9个月,这种长时间的治疗易产生患者的依从性差,并产生明显的毒性及耐药性。鉴于其耐药性的不断增加和持留态分枝杆菌的潜伏传染特性,急需开发对耐药菌具有抗菌活性的新的结核病治疗药物,更重要的是这些新药能杀死持留细菌,并缩短治疗所需的时间。本文介绍具有发展潜力的新的治疗结核的化学治疗药物。
Although great progress has been made in the treatment and immunization of tuberculosis, tuberculosis remains the major infectious disease, and although it can be cured, it takes at least 6 to 9 months. Such prolonged treatment tends to result in poor patient compliance , And produce significant toxicity and resistance. In view of their increasing drug resistance and the latent infection characteristics of mycobacteria, there is an urgent need to develop new TB drugs that have antibacterial activity against resistant bacteria, and more importantly, these new drugs can kill bacteria that persist and shorten the treatment The time required. This article presents new potential chemotherapeutics for the treatment of tuberculosis.