牙周鲁菲尼神经末梢是牙周膜内的一种低阈值慢适应力感受器,具有典型的形态特征。在牙周鲁菲尼神经末梢的发育、再生和改建中,神经营养因子及其受体起关键性作用,牙周组织中的终末神经膜细胞也可能参与其中。咬合关系变化和正畸移动力等牙周力环境的改变,可引起牙周鲁菲尼神经末梢的形态和功能改变。本文就其形态学特征及其与神经营养因子、终末神经膜细胞、力环境改变的关系等研究进展作一综述。 Periodontal Ruffini nerve endings are a type of low-threshold slow-response sensory receptors in the periodontal ligament with typical morphological features. Neurotrophic factors and their receptors play a key role in the development, regeneration, and remodeling of the Ruffini nerve endings in the periodontal tissue, and terminal nerve membrane cells in periodontal tissues may also be involved. Changes in occlusal relationship and orthodontic force and other changes in the periodontal environment, can cause changes in the morphology and function of the periodontal Lufuni nerve endings. This article reviews the morphological features and the relationship with the changes of neurotrophic factors, terminal mesangial cells and force environment.