目的　探讨脑垂体对细胞因子水平的影响。方法　采用生物活性法检测去脑垂体大鼠血清细胞因子IL 2、IL 6、TNF水平及应用放射免疫分析法检测垂体GH、TSH、PRL水平。结果　SD大鼠切除脑垂体后血清中GH、TSH、PRL水平均显著下降 ,血清中细胞因子IL 2、TNF活性均显著性降低 ,但IL 6无明显改变。结论　切除大鼠脑垂体后将影响了其免疫功能 ,证明脑垂体分泌正常的GH、TSH、PRL水平对维持正常的细胞因子水平有重要的作用 Objective To investigate the effect of pituitary gland on cytokine levels. Methods The levels of cytokines IL 2, IL 6, TNF in pituitary rats were measured by bioactivity method and the levels of pituitary GH, TSH and PRL were detected by radioimmunoassay. Results The serum levels of GH, TSH and PRL in SD rats decreased significantly after the resection of pituitary gland. The levels of IL 2 and TNF in serum decreased significantly, but IL 6 did not change significantly. Conclusion Excision of the pituitary gland in rats will affect its immune function and demonstrate that the normal secretion of GH, TSH and PRL in the pituitary gland plays an important role in maintaining normal cytokine levels