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目的:检测手足口病患儿的NT-proBNP水平,分析NT-proBNP对手足口病患儿诊断和病情评估的价值。方法:选择急性期HFMD患儿40例(其中,危重组11例,重症组13例,普通组16例),同时选择非HFMD发热儿童30例为发热组,健康体检儿童30例为正常对照组。测定各组的血清NT-proBNP水平。结果:急性期HFMD患儿的血清NT-proBNP水平明显高于发热组和正常对照组(P<0.01);危重组患儿的血清NT-proBNP水平明显高于重症组、普通组(P<0.01);重症组的血清NT-proBNP水平高于普通组(P<0.05)。结论:HFMD患儿的血清NT-proBNP水平升高,且危重症较重症和普通症升高明显,对HFMD病情评估具有一定的参考价值。
Objective: To detect the level of NT-proBNP in children with hand-foot-mouth disease and analyze the value of NT-proBNP in the diagnosis and assessment of hand-foot-mouth disease in children. Methods: 40 children with acute HFMD were selected, including 11 critically ill patients, 13 critically ill patients and 16 normal subjects. 30 non-HFMD fever children were selected as fever group and 30 healthy children were selected as normal control group . Serum NT-proBNP levels were measured in each group. Results: Serum NT-proBNP levels in children with HFMD in acute stage were significantly higher than those in fever group and normal control group (P <0.01). Serum NT-proBNP levels in critically ill children were significantly higher than those in severe group and normal group (P <0.01) ); Serum NT-proBNP levels in severe group were higher than those in normal group (P <0.05). Conclusion: Serum NT-proBNP levels are elevated in children with HFMD, and the severity of critically ill patients and common diseases are significantly elevated, which may be of reference value for the assessment of HFMD.