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早在1931年已观察到内毒素可使小鼠移植瘤出血坏死。已证实内毒素的抗肿瘤作用是宿主介导的免疫反应。这种反应的介质是肿瘤坏死因子(TNF)。体外实验表明,白细胞系统产生两种不同的TNF,植物血凝素刺激的淋巴细胞产生TNF-β,又称淋巴毒因子。激活的巨噬细胞(M(?))是TNF-α的来源,通称的TNF是指TNF-α。两者具有30%的同源性。目前利用基因工程能大量制备供临床使用的TNF。本文介绍TNF的药理作用、毒性及临床试用情况。
As early as 1931, it has been observed that endotoxin can cause hemorrhagic necrosis in mouse xenografts. It has been demonstrated that the anti-tumor effect of endotoxin is a host-mediated immune response. The medium for this reaction is tumor necrosis factor (TNF). In vitro experiments show that the white blood cell system produces two different TNF, phytohemagglutinin-stimulated lymphocytes produce TNF-β, also known as lymphotoxin. Activated macrophages (M (?)) Are a source of TNF- [alpha], and generic TNF refers to TNF- [alpha]. Both have 30% homology. At present, gene engineering can be used to prepare a large amount of TNF for clinical use. This article describes the pharmacological effects of TNF, toxicity and clinical trial situation.