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目的分析某医院抗菌药物使用强度及医务人员手卫生依从性对医院感染MRSA检出率的影响,为临床合理用药和医院感染控制提供参考。方法收集2012-2013年医院住院患者抗菌药物使用强度、医务人员手卫生依从性及医院感染MRSA检出率,并统计其数理相关关系;数据录入EXCEL数据库后,采用SAS8.2统计软件进行统计。结果 2012-2013年住院患者抗菌药物及β-内酰胺类抗菌药物使用强度分别从78.2、49.2分别下降至39.4和22.8,医务人员手卫生依从率从约25.0%提高至>60.0%,医院感染MRSA检出率从55.2%持续下降至28.0%;医院感染病例中MRSA检出率与同期住院患者抗菌药物使用强度、β-内酰胺类抗菌药物使用强度有相关性,相关系数分别为0.724、0.784,相关关系差异有统计学意义。结论通过规范抗菌药物使用,落实多药耐药菌隔离措施特别是手卫生措施,积极开展细菌耐药性监测,能有效减少细菌耐药性的产生。
Objective To analyze the influence of antibacterial use intensity and hand hygiene compliance of hospital staff on the detection rate of MRSA in hospital and provide a reference for clinical rational drug use and hospital infection control. Methods Intensive use of antimicrobial agents, hand hygiene compliance and hospital infection rate of MRSA in hospitalized patients from 2012 to 2013 were collected and their correlations were calculated. Data were entered into the EXCEL database and statistically analyzed using SAS8.2 statistical software. Results The inpatient use of antimicrobial agents and β-lactam antibiotics decreased from 78.2 to 49.2 in 2012 to 2013 respectively to 39.4 and 22.8, respectively. The hand hygiene compliance rate of medical staff increased from 25.0% to 60.0%. The prevalence of hospital-acquired MRSA The detection rate of MRSA decreased continuously from 55.2% to 28.0%. The detection rate of MRSA in hospital infection was correlated with the strength of antimicrobial agents and the strength of β-lactam antibiotics in hospitalized patients, the correlation coefficients were 0.724,0.784, The correlation was statistically significant. Conclusion By regulating the use of antibacterial drugs and implementing isolation measures of multidrug-resistant bacteria, especially hand hygiene measures, the monitoring of bacterial drug resistance is actively carried out, which can effectively reduce the emergence of bacterial drug resistance.