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目的分析妊娠期妇女阴道微生态状况的纵向变化。方法选择健康无症状单胎妊娠期妇女50例,分别于孕早期(10.2±2.1)周、孕中期(24.6±3.7)周、孕晚期(33.2±3.4)周,取其阴道分泌物,进行pH、H2O2含量检测及细菌培养,并经革兰染色后在油镜下观察,进行阴道微生态(阴道菌群的密集度、多样性、优势菌、炎症反应状况等)状况评价。结果 (1)50例孕妇中,孕早期38例(76%)阴道微生态正常,其中31例(81.58%)整个孕期维持阴道微生态正常,7例(18.42%)孕妇于孕中期或孕晚期转变为阴道微生态失调;12例(24%)孕早期阴道微生态失调,其中6例(50%)于孕中期或孕晚期转变为阴道微生态正常。(2)无症状性细菌性阴道病随着孕周增加部分可自然消退40%(2/5)。(3)H2O2阳性、阴道pH低者易从阴道微生态失调转为阴道微生态正常。结论妊娠期阴道微生态是动态变化的,部分细菌性阴道炎可自然消退,H2O2阳性及低阴道pH为维持正常阴道微生态的重要因素。
Objective To analyze the longitudinal changes of vaginal microflora in pregnant women. Methods Fifty healthy singleton women with asymptomatic pregnancy were selected and their vaginal secretions were collected during the first trimester (10.2 ± 2.1) weeks, second trimester (24.6 ± 3.7) weeks and third trimester (33.2 ± 3.4 weeks) , Detection of H2O2 content and bacterial culture. The cells were observed under an oil microscope after Gram stain. The vaginal microflora (density, diversity, dominant bacteria, inflammatory reaction status, etc.) of the vagina was evaluated. Results (1) Among 50 pregnant women, 38 (76%) pregnant women had normal vaginal microecology, of which 31 (81.58%) maintained normal vaginal microflora during pregnancy and 7 (18.42%) pregnant women were pregnant during the second trimester or third trimester of pregnancy Into vaginal microecosystem disorders; 12 cases (24%) vaginal microflora imbalance in early pregnancy, of which 6 (50%) in the second trimester or third trimester of vaginal microflora into normal. (2) Asymptomatic bacterial vaginosis with natural part of the increase can be subsided 40% (2/5). (3) H2O2 positive, vaginal pH is easy to change from vaginal microecosystem disorders vaginal microecology normal. Conclusions Gestational vaginal microecology is dynamically changing. Some bacterial vaginitis can subside spontaneously. H2O2 positive and low vaginal pH are important factors in maintaining normal vaginal microflora.