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目的 探讨肉碱对不全饥饿大鼠脂肪利用的影响。方法 用限食的方法造成不全饥饿大鼠模型 ,在给予高脂饲料基础上观察对照组与给予肉碱的实验组血浆肉碱浓度、附睾脂肪垫重量、粪便中脂肪含量、尿酮体、糖原等指标的变化。结果 补充肉碱后 ,实验组动物血浆总肉碱浓度显著高于对照组 ( P<0 .0 0 1 ) ;附睾脂肪组织重量及粪便中脂肪含量均显著低于对照组 ( P<0 .0 5) ,而肝糖原和肌糖原含量显著高于对照组 ( P<0 .0 5) ;实验前期和中期实验组尿酮体排出减少 ,与对照组相比 P<0 .0 5。结论 补充肉碱对不全饥饿大鼠脂肪利用有一定的促进作用
Objective To investigate the effects of carnitine on fat utilization in rats with incomplete hunger. Methods The rat model of incomplete hunger was induced by the limited feeding method. The plasma carnitine concentration, epididymal fat pad weight, fat content in feces, urine ketone body, glycogen, etc. were observed in the control group and the carnitine-treated experimental group on the basis of high fat diet Changes in indicators. Results After carnitine supplementation, total carnitine concentration in experimental group was significantly higher than that in control group (P <0.01); epididymal fat mass and fat content in feces were significantly lower than those in control group (P <0. 0 5), while the contents of hepatic glycogen and muscle glycogen were significantly higher than those in the control group (P <0.05). The excretion of urinary ketone bodies in the experimental group was lower than that in the control group (P <0.05). Conclusion Carnitine supplementation may promote the adipose tissue utilization in rats with incomplete hunger