以聚四氟乙烯人造血管为主体,两端压制钛金属支撑环集成构建一种新型复合型人工气管。制作犬颈段气管缺如模型,用复合人工气管重建呼吸道。通过犬体内移植动物实验观察复合型人工气管初步效果和影响长期生存的因素。直接移植复合人工气管作为对照组(n=8),复合人工气管移植后加生长因子等改善组织环境作为实验组(n=8)。术后定期气管镜检查以及处死后组织检查评价复合型人工气管移植效果。16只实验动物复合型人工气管均顺利完成移植,无手术死亡。一月后各组吻合口处有肉芽增生。对照组4只犬因移植后呼吸困难死亡,实验组有2只死亡。死亡犬经解剖标本显示吻合口感染、裂开,气道狭窄,人工气管移位脱落。其余犬按计划14月后处死。实验组平均生存时间长于实验组(558.6dvs 401.8d,P<0.05);实验组吻合口感染、裂开、重度狭窄以及意外死亡的发生率均低于对照组(P<0.05)。犬处死后解剖显示复合人工气管已被纤维组织包裹,人工气管腔内未见内膜生长。以聚四氟乙烯为主体连接支撑钛环的新型复合型人工气管替代自体气管重建气道,恢复气道通畅性,能保持移植物不变形。人工气管的复合设计减轻了吻合口狭窄,而感染和裂开仍是复合型人工气管移植的主要并发症,影响动物长期生存。应用生长因子改善局部环境可促进组织愈合。 Teflon-based artificial blood vessels as the main body, both ends of the titanium support ring compression integrated construction of a new type of composite trachea. Production of dog neck trachea lack of model, the use of composite artificial tracheal reconstruction of the respiratory tract. In vivo experimental animals were used to observe the preliminary effect of compound tracheal tubes and the factors affecting the long-term survival. The composite artificial trachea was directly transplanted as the control group (n = 8), and the composite artificial tracheal transplantation with growth factors and other organizations to improve the tissue environment as the experimental group (n = 8). Postoperative regular bronchoscopy and post-mortem examination of composite artificial tracheal evaluation. 16 experimental animals with synthetic tracheal tubes were successfully completed transplantation, no operative death. After an anastomosis in January at each group granulation hyperplasia. Four dogs in the control group died of dyspnea after transplantation, and two died in the experimental group. Anatomical specimens of death dogs showed anastomotic infection, dehiscence, airway narrowing, tracheal displacement off. The remaining dogs were executed as planned in 14 months. The average survival time of the experimental group was longer than that of the experimental group (558.6d vs 401.8d, P <0.05). The incidences of anastomotic infection, dehiscence, severe stenosis and accidental death in the experimental group were all lower than those in the control group (P <0.05). After the dog was killed, the anatomy showed that the composite artificial trachea was wrapped by the fibrous tissue, and no endometrial growth was found in the artificial tracheal cavity. Teflon as the main support titanium ring composite new type of artificial tracheal instead of tracheal reconstruction of airways to restore airway patency, to maintain the graft does not deform. The composite design of artificial trachea ameliorates anastomotic stenosis, and infection and dehiscence are still the main complication of compound tracheal transplantation, affecting the long-term survival of animals. Application of growth factors to improve the local environment can promote tissue healing.