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目的 :探讨益气养阴清热法为基本治法配合化疗治疗急性髓细胞白血病的临床疗效。方法 :用黄芪、太子参、白术、生地、黄精、天门冬、麦门冬、白花蛇舌草、半枝莲、小蓟、蒲公英、甘草组方。配合 DA、HA、IA等联合化疗方案。部分 M3 患者应用维甲酸、亚砷酸治疗。部分患者静脉滴注榄香稀乳、参脉、丹参等辅助治疗。结果 :1 5 6例完全缓解 1 1 3例 ,完全缓解率 72 .4% ;部分缓解 2 0例 ,部分缓解率 1 2 .8% ;总缓解率 85 .3% ;3年生存率 37.2 % ,5年生存率 2 2 .1 %。 32例老年患者完全缓解率 43.8% ,明显低于其他年龄段 ( P<0 .0 1 )。应用维甲酸治疗的 1 8例 M3 完全缓解 1 5例 ,完全缓解率 83.3%。亚砷酸治疗 3例完全缓解 2例。结论 :益气养阴清热法作为中医的基本治法治疗急性髓细胞白血病符合临床实际。中西医结合治疗急性髓细胞白血病缓解率高 ,患者易于接受 ,有比较高的实用价值。其中提示老年患者治疗比较困难。
Objective: To investigate the clinical effect of Qi-supplementing and Yin-clearing heat therapy as the basic treatment in combination with chemotherapy for acute myeloid leukemia. Methods: With Astragalus, heterophylla, Atractylodes, habitat, Polygonatum, aspartame, wheat astringent, Hedyotis diffusa, Scutellaria barbata, thistle, dandelion, licorice prescription. With DA, HA, IA and other combination chemotherapy. Some M3 patients with retinoic acid, arsenic acid treatment. Some patients intravenous infusion of olive milk, ginseng, Salvia and other adjuvant therapy. Results: The complete remission was found in 115 cases with a complete remission rate of 72.4%. The partial remission rate was 20%, the partial remission rate was 12.2%, the total remission rate was 85.3%, and the 3-year survival rate was 37.2% , 5-year survival rate of 21.2%. The complete remission rate of 32 elderly patients was 43.8%, significantly lower than that of other age groups (P <0.01). Fifteen cases of complete remission were treated with retinoic acid in 18 cases, and the complete remission rate was 83.3%. Three cases of arsenic trioxide in 2 cases of complete remission. Conclusion: Yiqi Yangyin clearing heat therapy as a basic treatment of traditional Chinese medicine treatment of acute myeloid leukemia in line with clinical practice. The combination of traditional Chinese and Western medicine treatment of acute myeloid leukemia response rate is high, patients are easy to accept, have a higher practical value. Which prompted elderly patients more difficult to treat.