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目的探讨急性冠脉综合征(ACS)患者CD4+CD28-T细胞表面OX40和4-1BB的表达及其临床意义。方法采用流式细胞术检测57例ACS患者、46例稳定性心绞痛(SA)患者和60例健康体检者(HC)外周血CD4+CD28-T细胞表面OX40和4-1BB的表达。结果 HC组、SA组和ACS组,三组相比CD4+CD28-T细胞表面OX40的表达水平依次升高;HC组、SA组和ACS组,三组相比CD4+CD28-T细胞表面4-1BB的表达水平依次升高。结论 ACS患者外周血CD4+CD28-T细胞表面OX40和4-1BB表达上调。
Objective To investigate the expression of OX40 and 4-1BB on CD4 + CD28-T cells in patients with acute coronary syndrome (ACS) and its clinical significance. Methods Flow cytometry was used to detect the expressions of OX40 and 4-1BB on CD4 + CD28-T cells in 57 patients with ACS, 46 patients with stable angina (SA) and 60 healthy subjects (HC). Results Compared with CD4 + CD28-T cells, the levels of OX40 in HC group, SA group and ACS group were higher than those in HC group, SA group and ACS group -1BB expression levels in turn increased. Conclusion The expression of OX40 and 4-1BB on CD4 + CD28-T cells in peripheral blood of patients with ACS is up-regulated.