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神经病理痛发病机制相当复杂,是目前临床治疗的焦点问题,P2X4受体在神经病理痛发生中起到核心中介的作用。由于嗅鞘细胞具有在神经损伤修复方面的独特生物学特性,成为目前在神经病理痛方面最具有潜在的治疗手段。本文就嗅鞘细胞移植与P2X4受体介导的神经病理痛相关性研究进展作一综述。
The pathogenesis of neuropathic pain is quite complex and is the focus of current clinical treatment. P2X4 receptor plays a central role in the pathogenesis of neuropathic pain. Olfactory ensheathing cells have become the most potential treatment for neuropathic pain due to their unique biological properties in the repair of nerve injury. This review summarizes the progress of studies on the correlation between olfactory ensheathing cell transplantation and P2X4 receptor-mediated neuropathic pain.