类风湿因子(RF)可以在免疫测定中产生干扰,具有与免疫球蛋白(Ig)G Fc段结合的特点。 RF与试剂中的抗体结合,可造成测定的结果呈假阳性或假阴性。近来,随着免疫测定的普及和发展,RF对免疫测定的干扰现象不断被发现,并逐渐引起临床实验室的重视,但研究多限于个例分析。该文主要就RF对免疫测定的干扰机制、干扰的常见项目及消除RF干扰的方法进行综述。“,”Rheumatoid factor ( RF) can generate interference in the immunoassay,with the characteris-tics of binding with immunoglobulin( Ig) G Fc segment. RF binding with antibody for reagents in immunoas-say can cause false positive or false negative. With the popularization and development of immunoassay,the RF interference on immune continues to be discovered,and has attracted the attention of clinical laboratory, but mostly limited to case analysis. Here is to make a review of the interference mechanism of RF,interfer-ence test items and how to eliminate RF interference.