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复方18甲基炔诺酮/雌二醇透皮控释传递系统(LNG/E_2 TCDS)能同时恒速释放低剂量的LNG和E_2,在1周内维持一个平稳而有效的LNG血药浓度。药动学与药效学研究证明,该系统释放的LNG能达到血清LNG目标水平,产生有效的排卵抑制(6/6)。LNG/E_2 TCDS可望发展成为一种安全、有效、非侵入性的新型生育调节避孕制剂。
Compound 18 norgestrel / estradiol transdermal controlled release delivery system (LNG / E 2 TCDS) can simultaneously release low doses of LNG and E 2 at a constant rate and maintain a steady and effective blood LNG concentration within 1 week. Pharmacokinetics and pharmacodynamics studies have shown that the LNG released by the system can reach the target level of serum LNG, resulting in effective ovulation inhibition (6/6). LNG / E_2 TCDS is expected to develop into a safe, effective and non-invasive new fertility regimen.