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低氧对哺乳动物炎症性疾病的发生发展具有重要调节作用。牙周炎是人类常见的口腔慢性感染性疾病之一,其局部组织也存在低氧现象。大量研究表明,厌氧菌、牙合创伤、吸烟甚至炎症本身均能使牙周局部组织处于缺血和低氧状态,而低氧和炎症又可诱导局部细胞和组织产生适应性调节反应。其中重要的调节因子是低氧诱导因子-1(hypoxia inducible factor 1,HIF-1),可通过启动并调节多个基因的表达改变以维持低氧下细胞存活和组织中的氧稳态。本文就低氧和HIF-1在牙周炎中的作用机制、HIF-1的结构和功能调控、HIF-1对牙周组织再生修复的作用等作一综述。
Hypoxia plays an important regulatory role in the occurrence and development of inflammatory diseases in mammals. Periodontitis is one of the common oral chronic oral diseases in human beings. Hypoxia also exists in its local tissues. A large number of studies have shown that anaerobic bacteria, occlusal trauma, smoking and even inflammation itself can make periodontal local tissue in the state of ischemia and hypoxia, and hypoxia and inflammation can induce local adaptive modulation of cells and tissues. One of the most important regulators is hypoxia inducible factor-1 (HIF-1), which can be activated by regulating the expression of many genes to maintain the hypoxic cell survival and oxygen homeostasis. In this paper, the mechanisms of hypoxia and HIF-1 in periodontitis, the structure and function of HIF-1 and the role of HIF-1 in periodontal tissue regeneration and repair are reviewed.