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目的探讨中国汉族人群COPD吸烟史患者HHIP基因多态性与发生肺癌风险的相关性。方法以672例COPD患者作为研究对象,依据病情分为试验组(COPD合并肺癌患者,n=265)和观察组(单纯COPD患者,n=207),采用连接酶检测反应法对患者HHIP基因的多态性位点rs1489758、rs1489759、rs10519717、rs13131837、rs1492820、rs7689420进行多态性分析。对连锁不平衡性分析及SNP点基因型与肺癌风险进行Logistic回归分析。结果HHIP基因位点rs1489758、rs1489759、rs10519717、rs13131837、rs1492820、rs7689420经Hardy·Weinberg平衡检验,均符合H.W平衡定律(P>0.05),具有群体代表性。以是否合并肺癌为因变量,各研究位点基因型多态性为自变量,行Logistic回归分析(年龄、性别、吸烟状况进行校正),结果显示,HHIP基因位点rs1489758、rs1489759、rs10519717、rs13131837、rs1492820、rs7689420与COPD患者是否并发肺癌无统计学关系(P>0.05)。结论本研究未发现HHIP基因的6个多态性位点与中国汉族COPD患者的肺癌发病风险有明确相关性。
Objective To investigate the association between HHIP gene polymorphism and the risk of developing lung cancer in Chinese Han population with COPD smoking history. Methods A total of 672 patients with COPD were enrolled in this study. Patients were divided into experimental group (COPD patients with lung cancer, n = 265) and observation group (patients with COPD, n = 207) Polymorphism analysis of rs1489758, rs1489759, rs10519717, rs13131837, rs1492820, rs7689420 polymorphism sites. Logistic regression analysis was used to analyze the linkage disequilibrium and SNP genotype and lung cancer risk. Results HHIP loci rs1489758, rs1489759, rs10519717, rs13131837, rs1492820, rs7689420 were all consistent with H.W equilibrium law (P> 0.05) by Hardy Weinberg equilibrium test. Logistic regression analysis (age, sex and smoking status) was used to analyze whether the lung cancer was associated or not. The results showed that HHIP loci rs1489758, rs1489759, rs10519717, rs13131837 , Rs1492820, rs7689420 and COPD patients with concurrent lung cancer no statistical relationship (P> 0.05). Conclusions This study did not find a clear correlation between the six polymorphisms of HHIP gene and the risk of lung cancer in Chinese Han patients with COPD.