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目的 评价采用呼吸内科治疗方法对慢性阻塞性肺疾病合并呼吸衰竭进行治疗的效果。方法 对2018年1月至2019年6月到我院治疗的42例慢性阻塞性肺疾病合并呼吸衰竭通过采用呼吸内科治疗患者作为观察组，另外选择同期到我院进行治疗的同样例数的同等病例的经过常规治疗方法治疗的患者作为对照组，对不同治疗所取得的效果进行评价和比较。结果 ①观察组[95.24%（40/42）]治疗后的总有效率明显高于对照组[73.81%（31/42）]，有统计学差异（P＜0.05）。②观察组[7.14%（3/42）]的不良反应发生率明显“,”Objective To evaluate the efficacy of respiratory medicine in the treatment of chronic obstructive pulmonary disease with respiratory failure.Methods A total of 42 cases of chronic obstructive pulmonary disease with respiratory failure who came to our hospital for treatment from January 2018 to June 2019 were treated by respiratory medicine as the observation group， and the same number of patients who came to our hospital for treatment during the same period were selected as the observation group. The patients of the case who have been treated with conventional treatment methods are used as the control group to evaluate and compare the effects of different treatments. Results (1) The total effective rate of the observation group [95.24%(40/42)] after treatment was significantly higher than that of the control group [73.81% (31/42)]， with a statistical difference (P＜0.05). (2) The incidence of adverse reactions in the observation group [7.14% (3/42)] was significantly lower than that in the control group [26.19% (11/42)]， and there was a statistical difference (P＜0.05). (3) After 1 week of treatment in the observation group ， Blood gas conditions (PaO_2， PaCO_2， SaO_2， Pplat， etc.) were better than those of the control group， with statistical differences (P＜0.05). Conclusion Respiratory medicine methods for the treatment of chronic obstructive pulmonary disease combined with respiratory failure can improve the clinical efficacy， reduce the incidence of adverse reactions， and improve related functions. It is worth recommending.