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目的探讨系统性红斑狼疮疾病活动指数(SLEDAI)对临床治疗的指导作用。方法以SLEDAI对每一例SLE患者入院前10天内和出院时的活动性进行评价;根据患者病情分别给予泼尼松、甲泼尼龙冲击、环磷酰胺冲击治疗。以SPSS统计软件进行相应统计学分析。结果①入院前和出院时SLEDAI均值比较t=8.65,P<0.001;②不同治疗分数患者SLEDAI比较差异有显著性;③泼尼松用量、甲泼尼龙或CTX冲击治疗均与SLEDAI正相关;④不同的治疗方法与不同的器官/系统活动性有关。结论SLEDAI是一较好的评价SLE活动性的指标,对临床治疗有较好的指导作用。对不同的器官/系统受累,宜选择不同的治疗方案。
Objective To investigate the guiding role of SLEDAI in clinical treatment. Methods SLEDAI was used to evaluate the activity of SLE patients within 10 days before admission and at discharge from hospital. According to the patients’ condition, they were treated with prednisone, methylprednisolone and cyclophosphamide. SPSS statistical software for statistical analysis. Results ① The mean SLEDAI before admission and at discharge was 8.65, P <0.001; ②The difference of SLEDAI between different treatment scores was significant; ③ The dosage of prednisone, methylprednisolone or CTX impact treatment was positively correlated with SLEDAI; ④ Different treatments are associated with different organ / systemic activities. Conclusion SLEDAI is a good indicator to evaluate the activity of SLE and has a good guiding effect on clinical treatment. Different organs / systems involved, should choose a different treatment options.