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研究直肠肿瘤微血管密度 (MVD)与肿瘤生物学行为的关系。应用免疫组织化学方法检测 48例直肠癌、15例直肠管状腺瘤及 9例直肠绒毛状腺瘤的MVD。结果表明 ,直肠管状腺瘤MVD低于直肠绒毛状腺瘤 (P <0 0 5 ) ;直肠癌MVD与前两者比较差异有高度显著性 (P <0 0 1)。 48例直肠癌患者MVD与其淋巴结转移、远处转移、浸润深度有关 (P <0 0 5 ) ,而与患者的年龄、性别无关。显示MVD可作为判断直肠癌的预后指标。
To study the relationship between rectal tumor microvessel density (MVD) and tumor biological behavior. Immunohistochemistry was used to detect MVD in 48 cases of rectal cancer, 15 cases of rectal tubular adenoma and 9 cases of rectal villous adenoma. The results showed that the MVD of rectal tubular adenoma was lower than that of rectal villous adenoma (P <0.05). The difference between MVD and rectal carcinoma was significant (P <0.01). 48 cases of rectal cancer patients with MVD lymph node metastasis, distant metastasis, depth of invasion (P <0 05), but not with the patient’s age and gender. MVD can be used as a prognostic indicator of rectal cancer.