肥胖和代谢综合征可增加绝经后妇女乳腺癌的患病率。肥胖、代谢综合征和西方富于饱和脂肪酸的饮食习惯,这三者共同的特征是高水平的胆固醇循环。流行病学报道关于高水平的胆固醇循环、降胆固醇药物与乳腺癌之间的关系仍有争议,因此我们通过控制饮食和等热量饮食建立临床前动物模型模拟这一复杂状况。通过低脂肪/无胆固醇饮食喂养雌性SCID裸鼠,然后随机分成4组等热量饮食组:低脂肪/ Obesity and metabolic syndrome can increase the prevalence of breast cancer in postmenopausal women. Obesity, metabolic syndrome and the Western diet rich in saturated fatty acids, all three features are high levels of cholesterol cycle. Epidemiological Reports Regarding the high cholesterol cycle, the link between cholesterol-lowering drugs and breast cancer remains controversial, so we model this complex situation by establishing preclinical animal models of diet and isocaloric diets. Female SCID nude mice were fed a low-fat / cholesterol-free diet and then randomly divided into 4 groups of isocaloric diet groups: low fat /