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目的 :探讨间苯三酚静脉滴注联合坦索罗辛口服辅助体外冲击波碎石(ESWL)治疗泌尿系结石的临床疗效。方法 :以结石直径<0.6cm并行体外冲击波碎石(ESWL)后24h内的上尿路结石患者150例为研究对象,随机分为A组、B组及C组。所有患者给予常规治疗。A组给予间苯三酚注射液40mg溶于5%葡萄糖250ml注射液中静脉滴注,1次/日;B组给予坦索罗辛0.2mg,口服,1次/日;C组给予坦索罗辛联合间苯三酚注射液,其中坦索罗辛用法用量与B相同;间苯三酚注射液用法用量与A相同。治疗2周后比较3组患者的结石排出率、结石清除率、;平均结石排出时间、石街形成率、肾绞痛发作次数、镇痛药使用人次及治疗期间而不良反应发生情况。结果 :组间比较:治疗2周后,3组的结石排出率、结石清除率、平均结石清除时间、石街形成率、肾绞痛发作率及镇痛药使用率之间具有明显区别,差异具有统计学意义,3组之间的不良反应发生率比较无显著性差异。组内两两比较:C组的结石排出率及结石清除率显著高于另外两组,平均结石排出时间、肾绞痛发作率及镇痛药使用率显著低于另外两组,差异均具有统计学意义;C组的石街形成率显著低于A组,B组的平均结石排出时间明显短于A组。结论:间苯三酚静脉滴注联合坦索罗辛口服辅助ESWL可增加结石排出率,缩短结石排出时间,降低肾绞痛发作率及镇痛药使用率且药物不良反应发生率与单用坦索罗辛或间苯三酚无明显区别,是一种安全有效的上尿路结石治疗方案。
Objective: To investigate the clinical efficacy of intravenous infusion of phloroglucinol combined with tamsulosin oral assisted extracorporeal shock wave lithotripsy (ESWL) in the treatment of urinary calculi. Methods: A total of 150 patients with upper urinary tract calculi within 24 hours after ESWL and stones diameter <0.6cm were randomly divided into A, B and C groups. All patients were given routine treatment. A group was given phloroglucinol 40mg dissolved in 5% glucose 250ml injection, 1 / day; B group given tamsulosin 0.2mg, orally, 1 / day; C group given tamsulosin Rosein combined phloroglucinol injection, which use the same amount of tamsulosin and B; phloroglucinol injection usage and A the same. After 2 weeks of treatment, the stone discharge rate, stone clearance rate, average stone discharge time, the stone street formation rate, the number of renal colic episodes, the use of analgesics, and the adverse reactions during the treatment were compared among the three groups. Results: After two weeks of treatment, there was a significant difference between the three groups in stone discharge rate, stone clearance rate, average stone clearance time, stone street formation rate, incidence of renal colic and analgesic use rate, the difference With statistical significance, the incidence of adverse reactions among the three groups showed no significant difference. Group comparison of each other: C group of stone discharge rate and stone clearance rate was significantly higher than the other two groups, the average stone discharge time, incidence of renal colic and analgesic use was significantly lower than the other two groups, the difference was statistically The mean stone formation rate in group C was significantly lower than that in group A, and the average time to stone discharge in group B was significantly shorter than that in group A. CONCLUSION: The combination of phloroglucinol and tamsulosin with ESWL can increase the rate of stone excretion, shorten the time of stone excretion, reduce the incidence of renal colic and the rate of analgesic use, and the incidence of adverse drug reactions Sorosin or phloroglucinol no significant difference, is a safe and effective treatment of upper urinary tract stones.