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有机膦化合物在有机合成、催化、生化、医药以及材料等各个领域都起重要的作用.主要总结了本课题组近几年来在过渡金属催化磷—氢化合物的转化反应研究方面取得的进展,包括磷—氢化合物对各种碳—碳不饱和化合物的区域立体选择性加成反应、不对称磷—氢加成反应和磷—氢化合物与碳—氢和杂原子—氢化合物的氧化或脱氢偶联反应.我们开发的反应提供了一系列制备各类不同精细有机膦化合物的相对高效和高原子经济性的新方法,相关反应的机理也将做适当讨论.
Organic phosphine compounds play an important role in various fields such as organic synthesis, catalysis, biochemistry, medicine and materials, etc. The progress made in the transition metal-catalyzed transformation of phosphorus-hydrogen compounds by our group has been summarized mainly in recent years, including The stereospecific addition reaction of phosphorus-hydrogen compounds to various carbon-carbon unsaturated compounds in the region, the asymmetric phosphorus-hydrogen addition reaction and the oxidation or dehydrogenation of phosphorus-hydrogen compounds with carbon-hydrogen and heteroatom-hydrogen compounds Coupling Reactions We have developed a series of new reactions that provide a series of relatively efficient and high atom economy for the preparation of a wide range of different finely divided organic phosphine compounds, and the mechanics of the related reactions will also be discussed as appropriate.