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目的:分析80岁以上高龄高血压病与认知功能减退的关系。方法:对210例高血压病患者和140例非高血压患者采用简易精神状况检查表(MMSE)进行认知功能检查,并收集相关资料。结果:高血压病患者的MMSE总分,定向力和视空间觉得分明显低于非高血压病组,差异有统计学意义(P<0.05)。随着病程延长,各亚组MMSE得分的均值出现下降趋势,高血压病程≥40年患者MMSE得分明显低于<40年患者(P<0.01)。降压达标者MMSE得分明显高于未达标者(P<0.05)。按不同的血压程度分组进行Logistic回归分析发现高收缩压(≥160mmHg)、高脉压(≥60 mmHg)是高龄老人高血压病患者认知功能减退的独立危险因素。结论:收缩压、脉压、高血压病程、降压是否达标与高龄高血压病患者认知功能减退有关。
Objective: To analyze the relationship between hypertension and cognitive decline in elderly patients over 80 years old. Methods: 210 cases of hypertensive patients and 140 cases of non-hypertensive patients using mental state examination (MMSE) for cognitive function tests, and collect relevant information. Results: The scores of MMSE, orientation and visual acuity in patients with essential hypertension were significantly lower than those in non-hypertensive patients (P <0.05). With the prolongation of duration, MMSE scores of all subgroups showed a decreasing trend. MMSE scores of patients with hypertension ≥40 years were significantly lower than those of <40 years (P <0.01). The MMSE score of the pressure-relief standard was significantly higher than that of the non-compliance (P <0.05). Logistic regression analysis showed that high systolic blood pressure (≥160mmHg) and high pulse pressure (≥60mmHg) were independent risk factors of cognitive decline in elderly patients with hypertension. Conclusions: Systolic blood pressure, pulse pressure, duration of hypertension, whether or not blood pressure is lower than the standard are related to the decline of cognitive function in elderly patients with hypertension.