结直肠癌是临床诊治中最常见的消化道恶性肿瘤,其发病率位居胃肠道肿瘤的第2位,多见于直肠及直肠与乙状结肠交界处[1]。结直肠癌发病初期无特异性临床症状,主要表现为便血和排便习惯改变,往往易被患者忽视,导致该病确诊时多数已进展至中晚期,并发生转移,转移发生率高达50%~60%[2]。晚期结肠癌患者预后较差,且由于多数患者伴肝、肺部等远处转移,其治疗困难。FOLFOX4化疗方案是治疗晚 Colorectal cancer is the most common clinical diagnosis and treatment of gastrointestinal malignancies, the incidence of gastrointestinal tumors ranked No. 2, more common in the rectum and rectum and sigmoid junction [1]. Colorectal cancer early onset of non-specific clinical symptoms, mainly manifested as changes in blood in the stool and bowel habits, often easily ignored by patients, leading to the diagnosis of most of the disease has progressed to the late stage, and the occurrence of metastasis, the incidence of metastasis as high as 50% ~ 60 %[2]. The prognosis of patients with advanced colon cancer is poor, and most patients with liver, lung and other distant metastasis, the treatment difficult. FOLFOX4 chemotherapy is late treatment