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目的比较培门冬酶与左旋门冬酰胺酶在儿童急性淋巴细胞白血病诱导化疗中的毒副作用和临床疗效。方法将2010年10月-2012年1月我院100例儿童急性淋巴细胞白血病患者随机分成两组各50例,对照组使用培门冬酶治疗,观察组采用左旋门冬酰胺酶治疗,治疗结束后比较两组患者的毒副作用和临床疗效。结果两组完全缓解率、总有效率、不良反应情况无统计学差异(P>0.05);观察组用药次数和住院时间明显多于对照组,差异有统计学意义(P<0.05)。结论培门冬酶与左旋门冬酰胺酶诱导化疗儿童急性淋巴细胞白血病均有较好疗效,但培门冬酶用药次数和住院时间明显缩短,需在临床应用时加以注意。
Objective To compare the toxicity and clinical efficacy of pemetretase and levascal amidase in the induction of chemotherapy for childhood acute lymphoblastic leukemia. Methods From October 2010 to January 2012, 100 children with acute lymphoblastic leukemia in our hospital were randomly divided into two groups of 50 cases. The control group was treated with pemetretase. The observation group was treated with L-asparaginase. The treatment was ended After comparing the two groups of patients with toxic side effects and clinical efficacy. Results There was no significant difference in the complete remission rate, total effective rate and adverse reaction between the two groups (P> 0.05). The number of medication and hospital stay in the observation group were significantly more than those in the control group (P <0.05). Conclusion Pegasys and L-asparaginase induced chemotherapy in children with acute lymphoblastic leukemia have a good effect, but the number of pepsinase enzyme and hospitalization time was significantly shortened, need to be noted in clinical application.