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目的探索制备乙酰灯盏乙素苷元的方法。方法以灯盏乙素为起始原料,与乙酸酐和吡啶共回流,经一步反应获得四乙酰灯盏乙素苷元和部分乙酰化产物6,7,4’-O-三乙酰基灯盏乙素苷元。结果与结论采用“一锅法”合成了乙酰灯盏乙素苷元,总收率在80%以上。乙酰灯盏乙素苷元和其乙酰化产物6,7,4’-O-三乙酰基灯盏乙素苷元均是灯盏乙素结构改造和修饰的重要中间体。与现有的两步合成法相比,本方法具有合成路线短、收率高、反应条件简单等特点,该法为同时获得2个重要中间体提供了有价值的参考。
Objective To explore a method for preparing acetyl scutellarin. Methods Scutellarin was used as the starting material and refluxed with acetic anhydride and pyridine to obtain tetraacetyl scutellarin and partial acetylation product 6,7,4’-O-triacetyl scutellarin yuan. RESULTS AND CONCLUSIONS The scutellarin was synthesized by one-pot method with a total yield of more than 80%. Acetyl Scutellarin and its acetylation products 6,7,4’-O-triacetyl scutellarin are scutellarin structural modification and modification of important intermediates. Compared with the existing two-step synthesis method, the method has the advantages of short synthesis route, high yield and simple reaction conditions, and provides valuable reference for obtaining two important intermediates at the same time.