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蛋白多肽类药物已经成为国内外药学研究和开发的热点,文中介绍几种给药微粒载体在多肽蛋白类药物口服中的应用,分别阐述了纳米粒、微球、脂质体、微乳等的应用和研究新成果。上述新型给药微粒载体研究在蛋白多肽药物制备中取得较大进展,明显改善了蛋白多肽药物的稳定性和体内药动学性质,在蛋白多肽药物研究中有广阔的应用前景。
Protein peptide drugs have become the focus of pharmaceutical research and development both at home and abroad. The article introduces the application of several drug-loaded particle carriers in the oral administration of peptide and protein drugs, and respectively expounds the application of nanoparticles, microspheres, liposomes and microemulsions Apply and research new achievements. The above new drug delivery particle carrier made great progress in the preparation of protein polypeptide drugs, significantly improved the stability of protein peptide drugs and in vivo pharmacokinetic properties, and has broad application prospects in protein peptide drug research.