论文部分内容阅读
微小RNA(microRNA,miRNA)是一种长度为21～25个核苷酸组成的内源性非编码小分子RNA,可以通过与靶基因序列特异性翻译抑制的相互作用在转录水平对基因表达进行调节,从而参与多种重要的生物学进程。miRNA在人体肿瘤的发生和发展过程中发挥非常重要的作用,已发现若干miRNA与某些肿瘤的发生和发展有着密切的关系。不仅是组织中的miRNA,外周血循环中的miRNA也与肿瘤的发生和发展密切相关,部分可作为疾病的诊断标志物,为临床疾病的早期诊断提供了新思路。血中肿瘤特异性miRNA的检出对肿瘤的早期诊断具有至关重要的作用。
MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs of 21-25 nucleotides in length that target gene expression at the transcriptional level by interaction with sequence-specific translational repression of target genes Regulate, and thus participate in a variety of important biological processes. MiRNAs play a very important role in the development and progression of human tumors and several miRNAs have been found to be closely associated with the development and progression of certain tumors. Not only miRNAs in tissues but also miRNAs in peripheral blood are also closely related to the occurrence and development of tumors. Some of them can be used as diagnostic markers of diseases, providing new ideas for the early diagnosis of clinical diseases. Detection of tumor-specific miRNA in blood plays an important role in the early diagnosis of tumors.