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诸多神经精神性疾病的发生均伴有树突棘发育异常。免疫球蛋白超家族成员细胞间黏附分子5(intercellular adhesion molecule 5,ICAM5)是一个通过抑制树突棘成熟,将其维持在丝状形态的跨膜蛋白,它只表达于端脑兴奋性神经元,可能与树突棘发育、突触可塑性乃至学习记忆密切相关。现综述了ICAM5的发现和特征、分子结构、基因结构、在树突棘发育过程中的作用,以及与脆性X综合征等疾病的关系,试图为阐明发育阶段脑神经元异常树突棘形成的机制提供线索。
Many neuropsychiatric diseases are associated with dendritic spine dysplasia. Intercellular adhesion molecule 5 (ICAM5), a member of the immunoglobulin superfamily, is a transmembrane protein that is maintained in a filamentous form by inhibiting the maturation of dendritic spines. It is expressed only in cerebellum excitatory neurons , May be closely related to dendritic spine development, synaptic plasticity and even learning and memory. This paper reviews the findings and characteristics of ICAM5, its molecular structure, gene structure, its role in the development of dendritic spines and its relation to other diseases such as Fragile X syndrome. In order to elucidate the formation of abnormal dendrites in cerebral neurons during the developmental stages Mechanisms provide clues.