论文部分内容阅读
治疗抗精神病药物引起的迟发性运动障碍(TD)常采用既有拟胆碱作用又有抗胆碱酯酶作用的毒扁豆碱,但由于它的作用时间短和具有毒性,故其使用受到了限制。如应用卵磷酯则需大剂量,而胆碱又有鱼腥样气味等缺点。氨基四氢吖啶(Tacrine)是一种口服的具有抗胆碱酯酶作用的药物,它没有上述那些药物的副作用。近来曾用之来解除各种抗精神药物的中毒取得一些效果。Summers等已证实了Tacrine的中枢抗胆碱酯酶的作
Treatment of antipsychotic-induced tardive dyskinesia (TD) is commonly used both with choline and anticholinesterase effect of physostigna, but because of its short duration and toxicity, so its use by Limit Such as the application of lecithin requires large doses, while choline odor fishy and other shortcomings. Tacrine is an orally administered drug that has anticholinesterase activity without the side effects of those drugs. Recently, it has been used to relieve the poisonings of various antipsychotic drugs and achieve some results. Summers have confirmed the central anticholinesterase Tacrine