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目的:探讨降钙素原(PCT)及同型半胱氨酸(Hcy)与2型糖尿病合并冠心病患者冠状动脉(冠脉)病变的相关性。方法:入选121例2型糖尿病患者,分为单纯糖尿病组、糖尿病合并冠心病组(合并稳定型心绞痛组和合并急性冠脉综合征组),另取50例健康人为对照组。分析各组间一般临床资料,根据冠脉病变支数、Gensini评分及多元回归分析探讨糖尿病患者PCT及Hcy水平与冠脉病变的关系。结果:各组间Hcy、PCT水平比较,糖尿病合并稳定型心绞痛组、糖尿病合并急性冠脉综合征组显著高于健康对照组及单纯糖尿病组(均P<0.05);Hcy水平与PCT水平呈正相关关系(r=0.792,P<0.01);双支、三支冠脉病变组血清Hcy和PCT水平高于单支病变组(P<0.05);Logistic回归分析显示,Hcy、PCT、糖化血红蛋白是冠脉病变程度的独立危险因素。结论:2型糖尿病合并冠心病患者冠脉病变程度随血清Hcy和PCT水平增加而加重。
Objective: To investigate the correlation between procalcitonin (PCT), homocysteine (Hcy) and coronary artery disease (CAD) in type 2 diabetes mellitus patients with coronary heart disease. Methods: A total of 121 patients with type 2 diabetes mellitus were enrolled and divided into simple diabetic group, diabetes mellitus combined coronary heart disease group (with stable angina pectoris group and acute coronary syndrome group) and 50 healthy people as control group. The clinical data of each group were analyzed. The relationship between coronary artery lesion and PCT and Hcy levels in diabetic patients was analyzed according to the number of coronary lesions, Gensini score and multiple regression analysis. Results: The levels of Hcy and PCT in each group were significantly higher than those in stable angina pectoris group and diabetes mellitus with acute coronary syndrome group (P <0.05 or P <0.05). Hcy level was positively correlated with PCT level (R = 0.792, P <0.01). The serum Hcy and PCT levels in the two branches and three branches of coronary artery disease were significantly higher than those in the single vessel disease group (P <0.05). Logistic regression analysis showed that Hcy, PCT and glycosylated hemoglobin were the highest Independent risk factors for the degree of venous disease. Conclusion: The severity of coronary lesions in type 2 diabetic patients with coronary heart disease aggravates with the increase of serum Hcy and PCT levels.