论文部分内容阅读
实验在麻醉开胸狗身上进行。用装有微分器的八道生理功能记录仪测取左室肌收缩性能的等容收缩相指标:(1)左室内压最大变化速率(dP/dt max)和(2)心肌收缩成分缩短速度(V_(CE)):包括 V_(CE)的生理最大值(V_(pm))、同最高等容收缩压时的 V_(CE)(V_(CE)-cpip)和 V_(CE)的最大值(V_(max))等。同时,利用示波摄影装置摄制左室内压-压力变化速率环(P-dP/dt 环)和左室内压-压力对数值变化速率环(P-(dP/dt)/P 环)。讨论了两环的形态特征以及干扰两环图形的方法学因素。本文认为,摄制 P-dP/dt 环和 P-(dP/dt)/P 环的优点在于:可以在两环上分析心动周期中任一瞬间 P 与 dP/dt 以及 P 与(dP/dt)/P 的对应关系;依据这两项对应的压力-速率关系,可以方便且准确地在同一个 P-(dP/dt)/P 环上测取 V_(pm)、V_(CE)-(CPiP)和 V_(max)等一系列 V_(CE)指标。实验结果表明,dP/dt max 和 V_(CE)这两类指标对正性变力性干预都比较敏感,受负荷状态的影响较小,因而,对评定心肌收缩性能的急性改变,有较高价值。两类指标相比较,V_(CE)类对变力性干预的敏感性低于 dP/dt max,但对负荷状态的依赖性较小。因此,采用多个指标综合评定心脏功能,较单一指标为宜。
The experiment was performed on an anesthetic thoracotomy dog. The isometric contraction indexes of left ventricular muscle contraction were measured with eight physiological function loggers equipped with differentiator: (1) the maximum rate of change of left ventricular pressure (dP / dt max) and (2) the rate of shortening of myocardial contractile component (V_ (CE)), including the maximum value of V_ (CE) and the maximum value of V_ (CE) -cpip and V_ (CE) (V_ (max)) and so on. Meanwhile, left ventricular pressure-pressure rate of change (P-dP / dt ring) and left ventricular pressure-pressure change rate ring (P- (dP / dt) / P-ring) were recorded by using an oscillograph. The morphological characteristics of the two rings and the methodological factors that disturb the two rings are discussed. In this paper, the advantages of the P-dP / dt loop and the P- (dP / dt) / P loop are as follows: P and dP / dt and P and (dP / dt) / P, and V_ (pm), V_ (CE) - (CPiP) can be easily and accurately measured on the same P-dP / dt loop according to the corresponding pressure- ) And V_ (max) and a series of V_ (CE) indicators. The experimental results showed that dP / dt max and V CE were both sensitive to positive force intervention and less affected by the load state. Therefore, the acute changes of myocardial contractility were higher value. Compared with the two indexes, V_ (CE) is less sensitive to force intervention than dP / dt max, but less dependent on load. Therefore, the use of multiple indicators comprehensive assessment of cardiac function, rather than a single indicator is appropriate.