本文报道,用D-氨基半乳糖(D-GAIN)诱发大鼠急性肝衰竭。于大鼠D-GaIN中毒后24h,腹腔移植同种完整肝细胞,提高活存率为48％。移植破碎肝细胞无效,而且出现凝血系统紊乱现象。本实验通过肝脏病理现察及~3H-胸隙嘧啶核苷(~3H-TdR)肝内掺入量测定结果表明,早期移植完整肝细胞,能阻止肝损害发展,并能刺激和促进病肝细胞再生、复原等作用。 This article reports that D-galactosamine (D-GAIN) -induced acute liver failure in rats. In rats 24 h after D-GaIN intoxication, the same type of intact hepatocytes was transplanted into the abdominal cavity to improve the survival rate of 48%. Transplant fragmentation of liver cells is invalid, and the phenomenon of coagulation disorders. In this study, liver histopathology and intrahepatic incorporation of ~ 3H-thoracopyrimidine (~ 3H-TdR) results show that early transplantation of intact hepatocytes can prevent the development of liver damage, and can stimulate and promote the liver disease Cell regeneration, recovery and other effects.