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目的探讨血清总前列腺特异性抗原(T-PSA)、游离前列腺特异性抗原(F-PSA)和F-PSA/T-PSA比值(F/T)对前列腺癌的诊断和临床意义。方法应用全自动化学发光分析仪检测健康对照组(60例),前列腺增生组(BPH组,49例)及前列腺癌组(PCa组,28例)血清T-PSA、F-PSA含量,计算F-PSA/T-PSA比值,分析T-PSA、F-PSA/T-PSA不同取值水平对临床诊断前列腺癌的灵敏度、特异性及诊断准确性的影响。结果 PCa组和BPH组的血清总前列腺特异性抗原、游离前列腺特异性抗原含量都比健康对照组高,差异具有统计学意义(P<0.05),PCa组的F-PSA、T-PSA含量高于BPH组,而F/T却比BPH组低许多,差异具有统计学意义(P<0.05)。结论 T-PSA界值取4 ng/ml,F/T取<0.16能有效地筛检前列腺癌,在鉴别前列腺癌与前列腺增生中有重要的临床应用价值。
Objective To investigate the diagnostic value and clinical significance of total prostate specific antigen (T-PSA), free prostate-specific antigen (F-PSA) and F-PSA / T-PSA ratio (F / T) in prostate cancer. Methods The levels of T-PSA and F-PSA in healthy control group (60 cases), benign prostatic hyperplasia group (BPH group, 49 cases) and prostate cancer group (PCa group, 28 cases) were measured by automatic chemiluminescence analyzer -PSA / T-PSA ratio, and to analyze the effect of different levels of T-PSA and F-PSA / T-PSA on the sensitivity, specificity and diagnostic accuracy of clinical diagnosis of prostate cancer. Results The levels of total prostate specific antigen and free prostate specific antigen in PCa group and BPH group were significantly higher than those in healthy control group (P <0.05). The levels of F-PSA and T-PSA in PCa group were high In BPH group, F / T was much lower than that in BPH group (P <0.05). Conclusion T-PSA cutoff value of 4 ng / ml, F / T <0.16 can effectively screen prostate cancer in the identification of prostate cancer and benign prostatic hyperplasia have important clinical value.