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目的探讨中国居民肺癌发病与家族史关系,为预防肺癌发病提供理论依据。方法利用Meta分析对我国公开发表的肺癌发病与家族史关系的病例对照研究的文献资料进行定量综合分析。结果共6篇文献入选,累计肺癌病例1 559例,对照1 598例;异质性检验:Χ2=2871.55,df=5(P<0.001);家族史与肺癌发病的合并OR值为2.47(95%CI:1.92,3.18)。结论肿瘤家族史仍是肺癌发病的危险因素之一。
Objective To investigate the relationship between the incidence of lung cancer and family history in Chinese residents and provide a theoretical basis for preventing the occurrence of lung cancer. Methods Meta-analysis was used to conduct a quantitative and comprehensive analysis of the literature of case-control studies on the relationship between the incidence of lung cancer and family history published in China. Results A total of 6 articles were included in the study, including 1 559 cases of lung cancer and 1 598 cases of control. The heterogeneity test was X2 = 2871.55 and df = 5 (P <0.001). The OR of family history and lung cancer was 2.47 % CI: 1.92, 3.18). Conclusion The family history of cancer is still one of the risk factors of lung cancer.