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18β-甘草次酸半琥珀酸酯双钠盐,商品名生胃酮是目前广泛用于治疗消化道溃疡的有效药物。它的衍生物甘草次酸胆碱(G1y-cyrrhetinic Acid Choline,GAC)据国外报道具有镇咳作用。国产GAC最近由广东佛山制药厂用生胃酮的副产品合成,分子量为537.77,化学结构见图1。我们对GAC进行了初步药理研究,为本品临床试用镇咳,祛痰提供实验资料。方法与结果一、镇咳作用 1.GAC抑制枸橼酸引起豚鼠咳嗽作用方法:以枸橼酸引咳法,豚鼠体重300克左右,雌雄不拘,在4升的密闭玻罩
18β-glycyrrhetinic acid hemisuccinate bis-sodium salt, product name carbenoxolone is currently widely used in the treatment of peptic ulcer effective drugs. Its derivative G1y-cyrrhetinic Acid Choline (GAC) reported antitussive effect abroad. The domestic GAC was recently synthesized by Foshan Pharmaceutical Factory in Guangdong Province as a co-product of carbonic anhydrase, with a molecular weight of 537.77. The chemical structure is shown in Figure 1. We carried out a preliminary GAC pharmacological studies for the clinical trials of cough, expectorant to provide experimental data. Methods and Results First, the antitussive effect 1.GAC citrate citrate inhibit cough caused by guinea pigs Method: citric acid cough method, guinea pig weighing about 300 grams, both male and female, in a 4 liter closed glass cover