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本文试图阐述家属发病倾向和其主要易患因子如高脂血症、高血压和糖尿病发病率之间的相互关系,以期改善在流行地区预防早期冠心病的前景。方法:以芬兰东北部Karlia地区的二组年龄在56岁以下的邻近人群211人作为研究对象,其中50人患非致死性、55人患致死性心肌梗塞,53人为稳定性心绞痛,53人为健康对照。对受检对象与其配偶,以及1143名15岁以上的亲属作病史、体检,以及血清胆固醇与甘油三酯测定。芬兰饮食的脂肪摄入量约137克/天,80％为饱和动物脂肪。男女两性的正常最高血清胆固醇为340毫克/100毫升,甘油三酯正常最高值男性为205毫克/100毫升,女性为150毫克/100毫升。家属高脂血症群集的标准是至少亲属总数的30％(至少二人)患有高脂
This article attempts to elucidate the correlation between the incidence of familial inclinations and the prevalence of predisposing factors such as hyperlipidemia, hypertension and diabetes in order to improve the prospects of preventing early coronary heart disease in endemic areas. METHODS: Two hundred and seventy-one neighboring population of under age 56 in Karlia district of northeast Finland were enrolled. Among them, 50 were non-fatal, 55 were fatal myocardial infarction, 53 were stable angina and 53 were healthy Control. The subjects and their spouses, as well as 1143 relatives over the age of 15 for medical history, physical examination, and serum cholesterol and triglyceride determination. Finnish diet intake of fat about 137 grams / day, 80% of saturated animal fat. The normal and highest serum cholesterol for both men and women is 340 mg / 100 ml, the normal triglyceride maximum is 205 mg / 100 ml for men and 150 mg / 100 ml for women. Family members of the standard hyperlipidemia cluster is at least 30% of the total relatives (at least two) suffer from high fat