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目的 探讨非小细胞肺癌的微血管密度 (MVD)及其血管内皮生长因子 (VEGF)与MR动态增强指标间的关系。方法 3 3例经病理证实的NSCLC ,分析其MR动态增强的最大强化斜率 (Smax)和峰值到达时间 (TTP)。将Smax和TTP分别与肿瘤的病理类型以及免疫组化结果 (MVD、VEGF)进行相互比较。结果 (1)腺癌的Smax高于鳞癌 ,而TTP则低于鳞癌 ,它们间均有明显的统计学差异(Smax :t=3 .2 2 ,Ρ <0 .0 1和TTP :Z =-2 .795 ,Ρ <0 .0 5 ) ;(2 )腺癌的MVD和VEGF阳性数均高于鳞癌 ,它们之间的差异有统计学意义(MVD :t=6.3 4,P <0 .0 0 1;VEGF :Ρ =0 .0 15 <0 .0 5 )。结论 MR动态增强的Smax和TTP ,可以反映NSCLC的MVD和VEGF表达的高低 ,从而推测其肿瘤血管的生成状况
Objective To investigate the relationship between microvessel density (MVD), vascular endothelial growth factor (VEGF) and dynamic MR in non-small cell lung cancer. Methods Twenty-three NSCLCs confirmed by pathology were analyzed for maximum enhancement slope (Smax) and peak arrival time (TTP) of MR dynamic enhancement. Smax and TTP were compared with the pathological types of tumor and the results of immunohistochemistry (MVD, VEGF). Results (1) Smax in adenocarcinoma was higher than that in squamous cell carcinoma, while TTP was lower in squamous cell carcinoma than in squamous cell carcinoma (Smax: t = 3.222, P <0.01 and TTP: Z = -2.795, P <0.05). (2) The positive numbers of MVD and VEGF in adenocarcinoma were higher than those in squamous cell carcinoma, the difference was statistically significant (MVD: t = 6.34, P < 0 .0 0 1; VEGF: P = 0 .0 15 <0. 05). Conclusions The dynamic increase of Smax and TTP in MR can reflect the expression of MVD and VEGF in NSCLC so as to speculate the tumor angiogenesis