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目的掌握银川市孕妇和小月龄(0~7月)婴儿麻疹抗体水平,为制定麻疹免疫策略和防控措施提供科学依据。方法在全市各县、市、区中选取6个调查点(社区卫生服务站和乡镇卫生院);每个调查点各月龄随机收集2人,每个县区完成调查84人,全市共调查504人;在全市各县、市、区医院产科收集待分娩产妇及新生儿20对,每个县区完成调查20对,全市共调查120对;共计调查744人,采集血标本,检测麻疹IgG抗体,同时对被调查者进行问卷调查,分析麻疹抗体水平状况。结果 (1)120名健康孕妇麻疹IgG抗体阳性率为71.67%,孕妇抗体几何平均浓度(GMC)为263.81 mIU/ml。孕妇各年龄组之间抗体阳性率差异有统计学意义(χ~2=6.062,P=0.048)。(2)0~7月龄婴儿麻疹Ig G抗体阳性率分别为76.67%、51.43%、40.00%、27.78%、20.00%、19.72%、18.92%、14.93%。不同地区(χ~2=55.160,P<0.05)、不同民族(χ~2=6.930,P=0.031)、不同月龄(χ~2=132.921,P<0.001)、不同分娩方式(χ~2=24.250,P<0.001)的婴儿之间麻疹抗体阳性率差异有统计学意义。结论银川市孕妇及小月龄婴儿麻疹抗体水平整体较低,建议必要时对育龄期妇女进行婚前MV复种和研制适用于小月龄婴儿接种的新型疫苗,以降低婴儿的麻疹发病率。
Objective To understand the level of measles antibody in pregnant women and Xiaoyue (0 ~ 7 months) infants in Yinchuan and provide a scientific basis for formulating measles immunization strategies and prevention and control measures. Methods Six investigation points (community health service stations and township hospitals) were selected from all counties, cities and districts in the city. Two people were randomly collected from each survey point for each month, and 84 people were completed in each county. 504 people; in the city’s county, city, district hospital obstetric collection of maternal and newborn to be delivered 20 pairs of each county to complete the survey 20 pairs of the city a total of 120 pairs of survey; a total of 744 people surveyed, collecting blood samples for measles IgG Antibodies, at the same time, the respondents were surveyed to analyze the level of measles antibody. Results (1) The positive rate of measles IgG antibody in 120 healthy pregnant women was 71.67%, and that of the pregnant women was 263.81 mIU / ml. The positive rate of antibody among pregnant women of all age groups was statistically significant (χ ~ 2 = 6.062, P = 0.048). (2) The Ig G antibody positive rates of measles from 0 to 7 month old were 76.67%, 51.43%, 40.00%, 27.78%, 20.00%, 19.72%, 18.92% and 14.93% respectively. (Χ ~ 2 = 6.930, P = 0.031), different months (χ ~ 2 = 132.921, P <0.001) and different delivery methods = 24.250, P <0.001) of measles antibody positive rate difference was statistically significant. Conclusions The level of measles antibody in pregnant women and small-month-old infants in Yinchuan City is generally low. It is suggested that prenuptial MV multiple seedling should be carried out for women of childbearing age and new vaccines suitable for infant vaccination should be developed to reduce the incidence of measles in infants.