利多氟嗪(lidoflazine,利多氟拉嗪)属哌嗪类衍生物,具有扩张冠脉及动、静脉血管,对缺血性心脏的慢性及顽固性心绞痛有独特的疗效.Van Nueten发现本品有松弛血管、明显扩张外周血管,降低心脏前、后负荷,并降低心肌耗氧量。本品是阻断d-肾上腺素能受体而产生血管效应,能显著抑制Ca~(++)内流引起的皮肤血管收缩、显著扩张内脏血管,减少回心血量,降低室壁张力,但 Lidofluzine (lidoflazine) is a piperazine derivatives, with dilation of coronary arteries and veins, the ischemic heart of chronic and refractory angina has a unique effect .Van Nueten found that the goods have Relaxation of blood vessels, significant expansion of peripheral blood vessels, reduce heart before and after the load, and reduce myocardial oxygen consumption. This product is blocking the d-adrenoceptors and vascular effects, can significantly inhibit Ca ~ (++) influx caused by skin vasoconstriction, significant dilation of visceral blood vessels, reduce back to the amount of blood, reducing wall tension, but