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目的探讨小剂量锋克松的有效性与安全性。方法比较小剂量锋克松治疗组与常规剂量治疗组患者的热退时间、有效例数、肾功能损害例数、治疗前后肌酐清除率变化,并进行统计学分析。结果两组治疗有效率无明显差别(P=0.632)。而小剂量组肾功能损害明显较常规组少(1/27 VS 11/19)(P<0.01)。小剂量组治疗前后比较,肌酐清除率无明显变化(P>0.05);常规剂量组治疗后肾肌酐清除率明显下降,治疗前后比较差异具有统计学意义(P<0.01)。小剂量组平均热退时间为6.6 d,稍长于常规剂量组的平均5.9 d(P=0.042)。结论小剂量锋克松治疗老年患者真菌性血流感染疗效肯定,肾脏的毒副作用明显较少。
Objective To investigate the efficacy and safety of low dose Methods The comparison of the thermal back time, the effective number of cases, the number of renal dysfunction and the creatinine clearance before and after treatment were compared between the small dose of Fengxongsan and the conventional dose group, and the statistical analysis was made. Results There was no significant difference between the two groups (P = 0.632). However, the renal damage in the low-dose group was significantly less than that in the conventional group (1/27 vs 11/19) (P <0.01). There was no significant difference in creatinine clearance between the low-dose and low-dose groups before and after treatment (P> 0.05). The clearance rate of renal creatinine was significantly decreased in the conventional dose group after treatment, with significant difference before and after treatment (P <0.01). In the low-dose group, the average thermal back-off time was 6.6 days, slightly longer than the average of 5.9 days in the conventional dose group (P = 0.042). Conclusion The efficacy of fungicidal bloodstream infection in elderly patients with small doses of pinacidon is affirmative, and the side effects of kidney are obviously less.