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据《Lancet》2000年355卷第9213期报道 Ⅰ期子宫内膜癌由于复发率低和缺乏随机试验资料,对其是否进行术后放疗仍是个有争议的问题。荷兰鹿特丹大学医院C.L.Creutzberg医生等在一项多中心前瞻性随机试验中,对Ⅰ期子宫内膜癌病人术后骨盆部放疗是否可抑制局部转移复发和改善生存率进行了观察。Ⅰ期子宫内膜癌病人分为3级:深度(≥50％)侵入为1级,表皮(<50％)侵入为3级,介于二者之间为2级。19个放射肿瘤中心的715例病人,在经腹全子宫切除术和双侧输卵管、卵巢切除术(不切除淋巴腺)后,随机给予骨盆部放疗(46Gy)或不作进一步治疗(分别为放疗组和对照组)。第一研究终点是局部转移复发和死亡,第二终点是治疗相关的发病率和复发后的死亡率。 根据着重于治疗的原则进行分析。对715例中的714例进行了评估。平均随访52个月。结果表明,保险统计5年局部转移复发率,放疗组为4％,对照组为14％(P<0.001)。保险
According to Lancet, Volume 355, Issue 9213, 2000, stage I endometrial cancer is still a controversial issue regarding whether to have postoperative radiotherapy because of its low recurrence rate and lack of randomized trials. In a multicenter prospective randomized trial, C. Pelotzberg, MD, of the University of Rotterdam, The Netherlands, conducted a postoperative pelvic radiotherapy in stage I patients with endometrial cancer to suppress local metastasis and recurrence and improve survival. Stage I endometrial cancer patients are divided into three levels: depth (≥ 50%) invasion of grade 1, the epidermis (<50%) invasion of grade 3, between the two for the two. Seventeen patients with a total of 19 radiotherapy centers underwent radical hysterectomy and bilateral salpingo-tubal and ovariectomy (without removal of the lymph nodes), and were given pelvic radiotherapy (46Gy) randomly or without further treatment (radiotherapy group And control group). The first study end point was local metastasis recurrence and death, and the second end point was treatment-related morbidity and post-relapse mortality. According to the principle of focusing on treatment for analysis. 714 of 715 patients were evaluated. The average follow-up of 52 months. The results showed that the recurrence rate of 5-year local metastasis in insurance statistics was 4% in radiotherapy group and 14% in control group (P <0.001). Insurance