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目的 :证明 p5 3基因在以降低剂量率来减少高剂量率照射所致高畸形的发生到零的危险度这一个过程中是必不可少的。方法 :源于同一遗传学背景的 3种野生型 p5 3(+/ +)、p5 3(+/ - )和 p5 3(- / - )小鼠 ,分别于妊娠第 9.5～ 10 .5天接受高剂量率 (1.0 6 Gy/ m in)和低剂量率 (0
PURPOSE: To demonstrate that the p5 3 gene is essential in the process of reducing the dose rate to reduce the risk of high deformity to zero due to high dose-rate irradiation. METHODS: Three wild-type p5 3 (+ / +), p5 3 (+ / -) and p5 3 (- / -) mice from the same genetic background were received at 9.5 to 10.5 days of gestation High dose rates (1.0 6 Gy / min) and low dose rates (0