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为了观察我国研制的甲型肝炎减毒活疫苗 (甲肝活疫苗 )H2 株 (滴度为 10 6 5TCID50 /ml)与LA - 1株 (滴度为10 6 5TCID50 /ml)免疫原性及加强免疫后的抗体浓度 ,对两所幼儿园 3～ 6岁的儿童先进行初筛 ,将甲肝易感儿童列为观察对象 ,同时分为H2 株 (45人 )和LA - 1株 (43人 )两组 ,接种首针疫苗后 1个月采血 ,分离血清低温保存 ,间隔 12个月加强接种第 2针甲肝活疫苗 ,接种后 2～ 3个月采血 ,用统一试剂检测甲肝病毒抗体 (抗 -HAV)。结果显示 :首针接种后抗 -HAV总阳转率为 80 7% (71/ 88) ,H2 株和LA - 1株抗 -HAV阳转率分别为 82 2 %和79 1% ,几何平均浓度 (GMC)分别为 6 8 0mIU/ml和 83 8mIU/ml,抗体浓度≥ 2 0 0mIU/ml的分别占 17 8% (8/4 5 )和 2 3 3% (10 / 4 3)。间隔 12个月加强免疫后 ,抗 -HAV阳性率分别为 95 6 %和 97 7% ;抗体GMC分别为371 3mIU/ml和 312 1mIU/ml,抗体浓度≥ 2 0 0mIU/ml分别为 80 0 %和 79 1%。采用 0、12个月两针法接种国产甲肝活疫苗 (H2 株和LA - 1株 )效果良好
In order to observe the immunogenicity and immunization of H1 strain live attenuated vaccine (live hepatitis A vaccine) H2 strain (titer of 10 6 5 TCID50 / ml) and LA - 1 strain (titer of 10 6 5 TCID50 / ml) After screening the antibodies against hepatitis A (HA) in children aged 3 ~ 6 years old in two kindergartens, the subjects were divided into two groups: H2 (45) and LA - 1 (43) , One month after inoculation of the first dose of vaccine, blood was collected and the serum was separated at low temperature. The live vaccine of the second dose of hepatitis A was boosted 12 months apart and blood was collected 2 to 3 months after inoculation. The hepatitis A virus antibody (anti-HAV) . The results showed that the total positive conversion rate of anti - HAV was 80 7% (71/88) after the first inoculation, and the anti - HAV positive rates of H2 and LA - 1 were 82 2% and 79 1%, respectively. The geometric mean concentration (GMC) were 68.0mIU / ml and 83.8mIU / ml, respectively. The antibody titer was ≥ 2000 mlU / ml, accounting for 17.8% (8/45) and 23.3% (10/43) respectively. The positive rates of anti-HAV were 95 6% and 97 7% respectively after boosting 12 months apart. The antibody GMC were 371 3mIU / ml and 312 1mIU / ml respectively. The antibody titer ≥ 200 mlU / ml was 80 0% And 79 1%. Inoculation of live attenuated hepatitis A vaccine (H2 strain and LA - 1 strain) with two and one needles at 0 and 12 months