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丝虫病是一种严重危害人类健康的疾病,全球约有1.5亿人受感染,引起严重的河盲症和象皮肿等后果。目前治疗丝虫病的药物包括伊维菌素、海群生等,主要作用于成熟的微丝蚴,而对成虫和早期的胚胎没有效果,导致丝虫病程的延续和服药时间的延长。自从专性细胞内寄生菌Wolbachia在丝虫体内发现以来,引起了人们的极大关注。研究表明,它对丝虫的生长发育,生殖和感染宿主后的免疫反应等都起重要的作用。本文就丝虫和其共生体Wolbachia的关系以及Wolbachia作为杀灭丝虫新的靶标的研究进行综述。
Filariasis is a disease that is seriously detrimental to human health. About 150 million people are infected worldwide, causing serious consequences such as river blindness and elephantiasis. The current treatment of filariasis drugs include ivermectin, sea qun, etc., mainly act on the mature microfilariae, but no effect on adult and early embryos, resulting in the continuation of filariasis duration and medication time. Since the obligate intracellular parasite Wolbachia was found in filarial body, it attracted great attention. Studies have shown that it plays an important role in the growth and development of filarial worms, reproductive and host immune response after infection. This article reviews the relationship between Wolbachia, a filamentous worm and its symbiont, and Wolbachia as a novel target for the killing of filariasis.