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结晶化作为一种改善药物稳定性和疗效的有效途径而广泛应用于制药领域,但蛋白质晶体由于复杂的结晶行为限制了其在药物传递系统中的广泛应用。随着蛋白质结晶技术的不断发展及其工业化应用,蛋白质晶体作为一种新型的生物大分子给药系统日益受到关注。热力学稳定的晶体结构可提高蛋白质类药物的理化稳定性,并具有缓释性能。本文根据近年文献报道,介绍了蛋白质晶体作为药物传递系统的研究现状和进展,并系统阐述了蛋白质结晶的基本过程、制备方法及应用特点。
Crystallization is widely used in the pharmaceutical field as an effective way to improve the stability and curative effect of drugs. However, the crystallization of protein limits its extensive application in drug delivery system due to the complicated crystallization behavior. With the continuous development of protein crystallization technology and its industrial application, protein crystal is attracting more and more attention as a new type of biological macromolecular drug delivery system. The thermodynamically stable crystal structure increases the physical and chemical stability of proteinaceous drugs and has sustained-release properties. In this paper, based on recent reports in the literature, the current status and progress of protein crystals as drug delivery systems are introduced. The basic process, preparation methods and application characteristics of protein crystals are systematically described.