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本文报道1例慢性乙型肝炎患者服用阿德福韦酯后发生Fanconi综合征。患者的临床症状出现时间与服用阿德福韦酯时间平行、而在停用阿德福韦酯并补充枸橼酸钾后临床症状缓解,诊断为阿德福韦酯相关Fanconi综合征。复习文献发现,阿德福韦酯治疗导致的Fanconi综合征存在剂量依赖性、时间依赖性及可逆性,其中小剂量阿德福韦酯(10mg/d)治疗慢性乙型肝炎后出现Fanconi综合征的均为亚裔人群。因此,凡服用阿德福韦酯的患者,无论剂量大小,均需定期进行相关检查,以监测是否发生Fanconi综合征。一旦发生,应立即换用其他抗病毒药物。
This article reports a case of chronic hepatitis B patients taking adefovir dipivoxil occurred after Fanconi syndrome. The patient developed clinical symptoms parallel to the time taken with adefovir dipivoxil, and the clinical symptoms were relieved after adefovir dipivoxil and potassium citrate supplementation were discontinued, diagnosing adefovir dipivoxil-associated Fanconi syndrome. Review of literature found that adefovir dipivoxil treatment-induced Fanconi syndrome in a dose-dependent, time-dependent and reversible, of which small doses of adefovir dipivoxil (10mg / d) treatment of chronic hepatitis B after Fanconi syndrome Are Asians. Therefore, all patients taking adefovir dipivoxil, regardless of dose size, are required to conduct regular checks to monitor Fanconi syndrome. In the event of any immediate replacement of other antiviral drugs.