论文部分内容阅读
目的观察培菲康联合锌制剂治疗婴幼儿肺炎继发性腹泻的临床效果。方法肺炎继发性腹泻的婴幼儿68例随机均分为两组,在规范化抗生素治疗的同时,对照组采用培菲康散剂治疗,联合组给予培菲康散剂加服无糖型赖氨葡锌颗粒。测定患儿治疗前及治疗后72h血浆二胺氧化酶活性及D-乳酸水平,比较两组疗效。结果治疗72h,两组患儿血浆二胺氧化酶活性和D-乳酸水平均较治疗前降低(P<0.05),且联合组低于对照组[(1.06±0.35)U/ml vs.(1.41±0.47)U/ml和(24.31±12.40)μg/ml vs.(32.68±15.44)μg/ml](P<0.05)。联合组总有效率为91.18%,高于对照组的73.53%(P<0.05)。结论在规范化抗生素治疗的基础上,加用培菲康和锌制剂是治疗婴幼儿肺炎继发性腹泻的有效方法。
Objective To observe the clinical effect of combination of pefloxacin and zinc in the treatment of secondary diarrhea in infants with pneumonia. Methods 68 cases of secondary diarrhea in infants and young children with pneumonia were randomly divided into two groups. In the course of standardized antibiotic treatment, the control group was treated with Peifeikang powder. The combination group was treated with Peifeikang powder plus glucosamine- Granules. The plasma diamine oxidase activity and D-lactate levels were measured before and 72 h after treatment in children. The curative effect was compared between the two groups. Results After 72 hours of treatment, plasma diamine oxidase activity and D-lactate level in both groups were lower than those before treatment (P <0.05), and the combined group was lower than the control group [(1.06 ± 0.35) U / ml vs. (1.41 ± 0.47) U / ml and (24.31 ± 12.40) μg / ml vs. (32.68 ± 15.44) μg / ml] (P <0.05). The combined group had a total effective rate of 91.18%, which was higher than that of the control group (73.53%, P <0.05). Conclusion On the basis of standardized antibiotic therapy, the combination of Pefikan and Zinc is an effective method for the treatment of secondary diarrhea in infants with pneumonia.