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肠溶衣的研究中寻找理想的包农材料与处方仍为目前迫切的问题,虫胶为我国目前广泛应用之肠衣材料,但由于它成分复杂且无恒定,故常呈现肠溶性能不稳定,包衣规格不易掌握。前人研究复方虫胶肠溶衣如萨罗、硬脂酸、蓖麻油结果不满意,我们仍以虫胶为主加一些附加物如胆盐、软肥皂、没食子酸等,组成复方肠溶衣处方,分别用以上处方包制乳酸钙、硫酸钡片,进行体外崩解度试验,并与目前公认为较理想的苯二甲酸醋酸纤维肠溶衣出较,以求获得一较理想的肠溶衣处方,此外亦初步探讨了虫胶肠衣的崩解机理。
Enteric-coated research to find the ideal package of agricultural materials and prescription is still an urgent issue, shellac is currently widely used in China casing material, but because of its complex composition and no constant, it often presents unstable enteric properties, including the package Clothing size is not easy to grasp. Previous studies of compound shellac enteric coating such as Salo, stearic acid, castor oil results are not satisfied, we are still based mainly shellac plus some additives such as bile salts, soft soaps, gallic acid, composed of compound enteric coating Prescriptions, respectively, with the above prescriptions made of calcium lactate, barium sulfate tablets, in vitro disintegration test, and with the current accepted as more ideal phthalic acid acetate enteric coating than in order to obtain a more ideal enteric Clothing prescription, in addition to also preliminary study shellac casing disintegration mechanism.