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目的 通过动物实验模型 ,探讨经腹主动脉旁插管化疗用于治疗恶性肿瘤腹膜后淋巴结转移的可行性、有效性及安全性。方法 雌性家兔 82只 ,分别采用腹主动脉旁插管和腹腔置管注入卡铂 ,用石墨炉原子吸收光谱法测定腹膜后淋巴结及其周围组织和血液的药物浓度 ,并观察淋巴结病理改变及注药前后血常规及生化检查。结果 ①经腹主动脉旁插管注药 ,药物可分布于腹主动脉旁淋巴结及盆腔淋巴结区域。②腹主动脉旁插管腹膜后化疗组腹膜后淋巴结内药物浓度高于腹腔化疗组。③腹主动脉旁插管化疗无明显毒副作用。结论 腹主动脉旁插管化疗可能是治疗妇科恶性肿瘤腹膜后淋巴结转移的简单、有效方法
Objective To investigate the feasibility, effectiveness and safety of transabdominal aortic catheterization for the treatment of retroperitoneal lymph node metastases in malignant tumors through an animal model. Methods Eighty-two female rabbits were used to inject carboplatin through abdominal aortic intubation and intraperitoneal catheter respectively. The concentration of drug in retroperitoneal lymph nodes and surrounding tissue and blood was measured by graphite furnace atomic absorption spectrometry, and the pathological changes of lymph nodes were observed. Blood tests before and after blood and biochemical tests. Results 1 By intra-abdominal aortic intubation, drugs can be distributed in the para-aortic lymph nodes and pelvic lymph nodes. 2 The concentration of drug in retroperitoneal lymph nodes of the abdominal aortic intubation retroperitoneal chemotherapy group was higher than that of the intraperitoneal chemotherapy group. 3 Abdominal aorta intubation chemotherapy has no obvious toxic side effects. Conclusion Abdominal aortic intubation chemotherapy may be a simple and effective method for the treatment of retroperitoneal lymph node metastasis in gynecologic malignancies